Where can I find the article "Metabolic Basis of Fibromyalgia & other Rela. Conditions by Garrison & Breeding
I know it was published in 2003, I think the publication is called Medical Hypothosis. The full title is Metabolic Basis of Firbomyalgia and Other Related Conditions and Possible Resistance to Thyroid Hormone by Richard Garrison and Paul Breeding from Houston, Texas
I found the following copy of the article it does have refference numbers that you should be able to access maybe with help from your local library.:
A metabolic basis for fibromyalgia and its related disorders: the possible role of resistance to thyroid hormone.
Journal: Med Hypotheses. 2003 Aug;61(2):182-9.
Authors: Garrison RL [1], Breeding PC.
[1] Corresponding author. Correspondence to: R.L. Garrison, MD, 3306 Montavesta Drive, Apt D70, Lexington, KY 40502, USA. Phone: 1-859-420-0888; Fax: 1-859-268-0026
Received 4 April 2000; accepted 10 October 2000; available online 11 June 2003. NLM Citation: PMID: 12888300
It has long been recognized that the symptom complex of fibromyalgia can be seen with hypothyroidism. Hypothyroidism may been categorized, like diabetes, into type I (hormone deficient) and type II (hormone resistant).
Most cases of fibromyalgia fall into the latter category. The syndrome is reversible with treatment, and is usually of late onset. It is likely more often acquired than due to mutated receptors. Now that there is evidence to support the hypothesis that fibromyalgia may be due to thyroid hormone resistance, four major questions appear addressable.
First, can a simple biomarker be found to help diagnose it? Second, what other syndromes similar to Fibromyalgia may share a thyroid-resistant nature? Third, in non-genetic cases, how is resistance acquired? Fourth, what other methods of treatment become available through this new understanding?
Preliminary evidence suggests that serum hyaluronic acid is a simple, inexpensive, sensitive, and specific test that identifies fibromyalgia. Overlapping symptom complexes suggest that chronic fatigue syndrome, Gulf war syndrome, premenstrual syndrome, post traumatic stress disorder, breast implant silicone sensitivity syndrome, bipolar affective disorder, systemic candidiasis, myofascial pain syndrome, and idiopathic environmental intolerance are similar enough to fibromyalgia to merit investigation for possible thyroid resistance.
Acquired resistance may be due most often to a recently recognized chronic consumptive coagulopathy, which itself may be most often associated with chronic infections with mycoplasmids and related microbes or parasites. Other precipitants of thyroid resistance may use this or other paths as well.
In addition to experimentally proven treatment with supraphysiologic doses of thyroid hormone, the thyroid-resistant disorders might be treatable with anti-hypercoagulant, anti-infective, insulin-sensitizing, and hyaluronolytic strategies.
I looked up both authors (separately) on Medscape, and this article did not appear, so it won’t be easy to find. I’d go to a Medical Library at a college nearest you and see if they can locate it for you, if you really want it.
References :
I found the following copy of the article it does have refference numbers that you should be able to access maybe with help from your local library.:
A metabolic basis for fibromyalgia and its related disorders: the possible role of resistance to thyroid hormone.
Journal: Med Hypotheses. 2003 Aug;61(2):182-9.
Authors: Garrison RL [1], Breeding PC.
[1] Corresponding author. Correspondence to: R.L. Garrison, MD, 3306 Montavesta Drive, Apt D70, Lexington, KY 40502, USA. Phone: 1-859-420-0888; Fax: 1-859-268-0026
Received 4 April 2000; accepted 10 October 2000; available online 11 June 2003. NLM Citation: PMID: 12888300
It has long been recognized that the symptom complex of fibromyalgia can be seen with hypothyroidism. Hypothyroidism may been categorized, like diabetes, into type I (hormone deficient) and type II (hormone resistant).
Most cases of fibromyalgia fall into the latter category. The syndrome is reversible with treatment, and is usually of late onset. It is likely more often acquired than due to mutated receptors. Now that there is evidence to support the hypothesis that fibromyalgia may be due to thyroid hormone resistance, four major questions appear addressable.
First, can a simple biomarker be found to help diagnose it? Second, what other syndromes similar to Fibromyalgia may share a thyroid-resistant nature? Third, in non-genetic cases, how is resistance acquired? Fourth, what other methods of treatment become available through this new understanding?
Preliminary evidence suggests that serum hyaluronic acid is a simple, inexpensive, sensitive, and specific test that identifies fibromyalgia. Overlapping symptom complexes suggest that chronic fatigue syndrome, Gulf war syndrome, premenstrual syndrome, post traumatic stress disorder, breast implant silicone sensitivity syndrome, bipolar affective disorder, systemic candidiasis, myofascial pain syndrome, and idiopathic environmental intolerance are similar enough to fibromyalgia to merit investigation for possible thyroid resistance.
Acquired resistance may be due most often to a recently recognized chronic consumptive coagulopathy, which itself may be most often associated with chronic infections with mycoplasmids and related microbes or parasites. Other precipitants of thyroid resistance may use this or other paths as well.
In addition to experimentally proven treatment with supraphysiologic doses of thyroid hormone, the thyroid-resistant disorders might be treatable with anti-hypercoagulant, anti-infective, insulin-sensitizing, and hyaluronolytic strategies.
References :